Recombinant thrombomodulin protects against LPS-induced acute respiratory distress syndrome via preservation of pulmonary endothelial glycocalyx.

Kodai SuzukiHideshi OkadaGenzou TakemuraChihiro TakadaHiroyuki TomitaHirohisa YanoIsamu MurakiRyogen ZaikokujiAyumi KurodaHirotsugu FukudaAyane NishioShigeo TakashimaAkio SuzukiNagisa MiyazakiTetsuya FukutaNoriaki YamadaTakatomo WatanabeTomoaki DoiTakahiro YoshidaKeisuke KumadaHiroaki UshikoshiShozo YoshidaShinji Ogura

Published in: British journal of pharmacology (2020)

Our findings show that rhTM treatment affected inflammation, cell proliferation/differentiation, and glycocalyx synthesis in serum and lung tissue, subsequently attenuating ARDS caused by endothelial injury.

Keyphrases

acute respiratory distress syndrome
lps induced
extracorporeal membrane oxygenation
mechanical ventilation
cell proliferation
inflammatory response
endothelial cells
oxidative stress
pulmonary hypertension
cell cycle