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Antipsychotics in the Treatment of Children and Adolescents with Anorexia Nervosa: A Systematic Review.

Jacopo PruccoliLuca BergonziniAngela La TempaAntonia Parmeggiani
Published in: Biomedicines (2022)
Evidence about the use of pharmacologic agents in the treatment of Anorexia Nervosa (AN) is lacking, especially in childhood and adolescence. A systematic scoping review was conducted to outline current literature evidence about the use of antipsychotics in this population. A total of 499 studies were identified with the initial search, and 28 of these studies were selected regarding the use of olanzapine (n = 13), risperidone (n = 4), aripiprazole (n = 3), chlorpromazine (n = 3), pimozide (n = 1) clotiapine (n = 1) and multiple antipsychotics (n = 3) in these patients. Overall, major side effects were reported infrequently; improvements in psychopathology and weight measures have been suggested in the majority of the considered studies. Nonetheless, the lack of RCT or good-quality studies strongly limits the generalizability of results in clinical practice.
Keyphrases
  • anorexia nervosa
  • case control
  • clinical practice
  • end stage renal disease
  • chronic kidney disease
  • newly diagnosed
  • physical activity
  • prognostic factors
  • young adults
  • weight gain
  • patient reported
  • body weight