A pathophysiological biomarker combination separates Lewy body from non-Lewy body neurogenic orthostatic hypotension .
Risa IsonakaPatti SullivanCourtney HolmesDavid S GoldsteinPublished in: Clinical autonomic research : official journal of the Clinical Autonomic Research Society (2024)
LB forms of nOH feature cardiac noradrenergic deficiency, olfactory dysfunction, and increased α-syn-TH colocalization in skin biopsies. Combining the data for these variables efficiently separates LB from non-LB nOH. Independently of the clinical diagnosis, this biomarker triad identifies a pathophysiologically distinct cluster of nOH patients.
Keyphrases
- end stage renal disease
- parkinson disease
- chronic kidney disease
- ejection fraction
- newly diagnosed
- spinal cord injury
- peritoneal dialysis
- machine learning
- prognostic factors
- oxidative stress
- genome wide
- left ventricular
- deep learning
- electronic health record
- heart failure
- soft tissue
- atrial fibrillation
- deep brain stimulation
- ultrasound guided
- wound healing
- data analysis