Relationship between brachial-ankle pulse wave velocity and invasively measured aortic pulse pressure.
Jeehoon KangHack-Lyoung KimWoo-Hyun LimJae-Bin SeoJoo-Hee ZoMyung-A KimSang-Hyun KimPublished in: Journal of clinical hypertension (Greenwich, Conn.) (2018)
Although brachial-ankle pulse wave velocity (baPWV) has been widely used as an index of arterial stiffness, no consensus exists about whether baPWV can reflect central aortic stiffness. The authors investigated the association between baPWV and invasively measured aortic pulse pressure (APP) in a total of 109 consecutive patients (mean age, 62.3 ± 11.3 years; 67.9% men). Most patients (91%) had obstructive coronary artery disease, and mean baPWV and APP values were 1535 ± 303 cm/s and 66.8 ± 22.5 mm Hg, respectively. In univariate analysis, there was a significant linear correlation between baPWV and APP (r = .635, P < .001). The correlation between baPWV and APP remained significant even after controlling for potential confounders (β = 0.574, P < .001; R2 = .469). Arterial stiffness measured by baPWV showed a strong positive correlation with invasively measured APP, independent of clinical confounders. Therefore, baPWV can be a good marker of central aortic stiffness.
Keyphrases
- blood pressure
- end stage renal disease
- aortic valve
- coronary artery disease
- chronic kidney disease
- left ventricular
- newly diagnosed
- pulmonary artery
- prognostic factors
- peritoneal dialysis
- heart failure
- cardiovascular disease
- coronary artery
- cardiovascular events
- aortic dissection
- risk assessment
- blood flow
- transcatheter aortic valve replacement
- middle aged
- atomic force microscopy
- fluorescent probe