Expansion of circulating peripheral TIGIT+CD226+ CD4 T cells with enhanced effector functions in dermatomyositis.

Wenli LiChuiwen DengHanbo YangXin LuShanshan LiXia LiuFang ChenLida ChenXiaoming ShuLu ZhangQingyan LiuGuochun WangQing-Lin Peng

Published in: Arthritis research & therapy (2021)

Our data revealed that the TIGIT and CD226 expression profiles could be used to identify functionally distinct subsets of CD4 T cells and TIGIT+CD226+ CD4 T cells is a significant subset in DM with enhanced frequency and effector function. This abnormal subset could be suppressed by blocking CD226, providing insight into the therapeutic target of the TIGIT/CD226 axis.

Keyphrases

regulatory t cells
metabolic syndrome
electronic health record
rheumatoid arthritis
systemic sclerosis
machine learning
interstitial lung disease
peripheral blood
single cell
weight loss
disease activity
artificial intelligence