Association between thiopurine exposure and depression in patients with inflammatory bowel disease and rheumatoid arthritis.

S Scott SuttonJoseph MagagnoliTammy CummingsJames W HardinBryan L Love

Published in: Journal of psychopharmacology (Oxford, England) (2020)

These results provide evidence that Rac1 regulation is a viable therapeutic target for depression. Further research into therapeutics targeting Rac1 for the treatment of depression is warranted.

Keyphrases

rheumatoid arthritis
depressive symptoms
patients with inflammatory bowel disease
sleep quality
small molecule
cancer therapy
cell migration
drug delivery
disease activity
combination therapy