NGF/anti-VEGF combined exposure protects RCS retinal cells and photoreceptors that underwent a local worsening of inflammation.

Maria Luisa RoccoBijorn Omar BalzaminoGraziana EspositoCarla PetrellaLuigi AloeAlessandra Micera

Published in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2016)

These data confirm and extend our previous findings on NGF-photoreceptor crosstalk, highlighting that the NGF/αVEGF combination might be an interesting approach for improving neuroprotection of RCS retinal cells and likewise photoreceptors in the presence of neovascularization. Further studies are required to translate this in vitro approach into clinical practice.

Keyphrases

induced apoptosis
vascular endothelial growth factor
diabetic retinopathy
growth factor
cell cycle arrest
clinical practice
optical coherence tomography
oxidative stress
endothelial cells
signaling pathway
brain injury
machine learning
cell proliferation
pi k akt
case control