Columbianadin attenuates doxorubicin-induced cardiac injury, oxidative stress, and apoptosis via Sirt1/FOXO1 signaling pathway.

Bo Peng Li Rao Jiaolong Yang Xiaowei Ku Bin Kong Wei Shuai He Huang

Published in: Acta cirurgica brasileira (2023)

Collectively, CBN attenuated oxidative stress and cardiomyocyte apoptosis in DOX-induced cardiotoxicity through maintaining Sirt1/FOXO1 signaling pathway. Our results demonstrated that CBN might be used to treat DOX-related cardiotoxicity.

Keyphrases

oxidative stress
diabetic rats
signaling pathway
pi k akt
induced apoptosis
high glucose
ischemia reperfusion injury
cell cycle arrest
dna damage
endoplasmic reticulum stress
epithelial mesenchymal transition
transcription factor
cell death
drug induced
endothelial cells
drug delivery
cell proliferation
heat shock