Lung Dysbiosis, Inflammation, and Injury in Hematopoietic Cell Transplantation.
David N O'DwyerXiaofeng ZhouCarol A WilkeMeng XiaNicole R FalkowskiKaty C NormanKelly B ArnoldGary B HuffnagleSusan MurrayJohn R Erb-DownwardGregory A YanikBethany B MooreRobert P DicksonPublished in: American journal of respiratory and critical care medicine (2019)
In animal models and human subjects, lung dysbiosis is a prominent feature of HCT. Lung dysbiosis is correlated with histologic, immunologic, and physiologic features of post-HCT pulmonary complications. Our findings suggest the lung microbiome may be an unappreciated target for the prevention and treatment of post-HCT pulmonary complications.