Heat shock and HSP70 regulate 5-FU-mediated caspase-1 activation in myeloid-derived suppressor cells and tumor growth in mice.

Thomas PilotAurélie FrattiChloé ThinselinAnaïs PerrichetLucie DemontouxEmeric LimagneValentin DerangèreAlis IlieMané NdiayeElise JacquinCarmen GarridoFrançois GhiringhelliFanny ChalminCédric Rebe

Published in: Journal for immunotherapy of cancer (2021)

This study provides evidence on the role of HSP70 in tuning 5-FU antitumor effect and suggests that HS can be used to improve 5-FU anticancer effect.

Keyphrases

heat shock
heat shock protein
heat stress
induced apoptosis
cell death
oxidative stress
cell cycle arrest
type diabetes
adipose tissue
signaling pathway
metabolic syndrome
skeletal muscle
high fat diet induced