Twin DNA Methylation Profiling Reveals Flare-Dependent Interferon Signature and B Cell Promoter Hypermethylation in Systemic Lupus Erythematosus.

Constance J Ulff-MøllerFazila AsmarYi LiuAnders J SvendsenFlorence BusatoKirsten GrønbaekJorg Tost Søren Jacobsen

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2018)

Hypomethylation of interferon-regulated genes occurs in all major cellular compartments in SLE-affected twins. The observed B cell promoter hypermethylation is a novel finding with potential significance in SLE pathogenesis.

Keyphrases

dna methylation
systemic lupus erythematosus
genome wide
transcription factor
disease activity
gene expression
dendritic cells
copy number
single cell
genome wide identification
human health
risk assessment
bioinformatics analysis
immune response