Repeat Next-Generation Sequencing Testing on Progression in Men With Metastatic Prostate Cancer Can Identify New Actionable Alterations.
Joseph J ParkShih-Chun A ChuJinju LiAlicia AliRana R McKayClara HwangMatthew Kyle LabriolaAlbert JangDeepak KilariGeorge MoDeepak RavindranathanLaura S GrahamAlexandra O SokolovaAbhishek TripathiAmanda PillingTanya JindalAditya RavindraFrank Cameron CackowskiPatrick L SweeneyBicky ThapaTaylor S AmeryElisabeth I HeathRohan GarjeYousef ZakhariaVadim S KoshkinMehmet Asim BilenMichael Thomas SchweizerPedro C BarataTanya Barauskas DorffMarcin P CieslikAjjai S AlvaAndrew J ArmstrongPublished in: JCO precision oncology (2024)
Repeat somatic NGS testing in men with prostate cancer is infrequently performed in practice and can identify new actionable alterations not present with initial testing, suggesting the utility of repeat molecular profiling with tissue or blood of men with metastatic castration-resistant prostate cancer to guide therapy choices.