Mutation profile differences in younger and older patients with advanced breast cancer using circulating tumor DNA (ctDNA).
Katherine K CliftonJingqin LuoYu TaoJennifer SaamThereasa RichAnna RoshalAshley FrithCaron RigdenFoluso AdemuyiwaKatherine WeilbaecherLeonel Hernandez-AyaLindsay L PetersonNusayba BagegniRama SureshRon BoseMateusz OpyrchalTanya M WildesCynthia MaPublished in: Breast cancer research and treatment (2020)
When controlling for subtype, results from a single institution were similar to the multi-institutional cohort showing that ATM and PIK3CA were more common in older adults. These data suggest there may be additional molecular differences in older adults with advanced breast cancers.