Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma.
Mohammad Harun-Or-RashidDenise M InmanPublished in: Journal of neuroinflammation (2018)
Our data demonstrate that the AMPK activation apparent in the glaucomatous retina and ON triggers NF-κB signaling and consequently induces a pro-inflammatory response. The ketogenic diet resolves energy demand and ameliorates the inflammation by inhibition of AMPK activation and stimulation of HCAR1-ARRB2 signaling that inhibits NLRP3 inflammasome-mediated inflammation. Thus, these findings depict a neuroprotective mechanism of the ketogenic diet in controlling inflammation and suggest potential therapeutic targets for inflammatory neurodegenerative diseases, including glaucoma.
Keyphrases
- inflammatory response
- oxidative stress
- nlrp inflammasome
- lps induced
- skeletal muscle
- optic nerve
- physical activity
- signaling pathway
- lipopolysaccharide induced
- mouse model
- electronic health record
- immune response
- toll like receptor
- magnetic resonance
- climate change
- risk assessment
- cerebral ischemia
- brain injury
- machine learning
- artificial intelligence
- diabetic retinopathy
- anti inflammatory
- optical coherence tomography
- diffusion weighted imaging
- data analysis
- subarachnoid hemorrhage