Selective Access to Functional Fluoroenones via Palladium-Catalyzed Selenofluoroalkylacylation of Terminal Alkynes.

Ya LiDian DongLintong ChenHongxuan DuCong ZhaoXiaoyan BaiLu Chen Yibiao Li Xianghua Zeng Pierre H Dixneuf Min Zhang

Published in: Organic letters (2024)

The trifluoromethylacyl group (-COCF 3 ) is an important motif and widely studied in catalysis, medicinal chemistry, and materials science. Herein, a novel palladium-catalyzed selenofluoroalkylacylation of terminal alkynes with commercially available fluoroalkyl anhydride and diorganyl diselenides to afford β-seleno and aryl/alkyl disubstituted enones under mild conditions is disclosed. In addition, selenodifluoroacetylations and selenoperfluoroacetylations are also suitable for this reaction. Mechanistic studies reveal that this reaction proceeds via an oxidative radical-polar crossover process.

Keyphrases

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