Genomic, functional and structural analyses elucidate evolutionary innovation within the sea anemone 8 toxin family.
Lauren M AshwoodKhaled A ElnahriryZachary K StewartThomas ShafeeMuhammad Umair NaseemTibor G SzantoChloé A van der BurgHayden L SmithJoachim M SurmEivind A B UndheimBruno MadioBrett R HamiltonShaodong GuoDorothy C C WaiVictoria L CoyneMatthew J PhillipsKevin J DudleyDavid A HurwoodGyorgy PanyiGlenn F KingAna PavasovicRaymond S NortonPeter J PrentisPublished in: BMC biology (2023)
Our results provide the first demonstration that SA8 is a unique gene family in Actiniarians, evolving through a variety of structural changes including tandem and proximal gene duplication and an inversion event that together allowed SA8 to be recruited into the venom of T. stephensoni.