Simultaneously controlling conformational and operational stability of single-chain polymeric nanoparticles in complex media.

Stefan WijkerRico MonninkLuc RijndersLinlin DengAnja R A Palmans

Published in: Chemical communications (Cambridge, England) (2023)

Single-chain polymeric nanoparticles (SCPNs) comprising a solvatochromic pyrazoline adduct show conformational and operational stability in complex media and in cellular compartments; the connectivity of the adduct is crucial in modulating interactions with the surrounding media.

Keyphrases

drug delivery
molecular dynamics
molecular dynamics simulations
single molecule
cancer therapy
drug release
signaling pathway
resting state
functional connectivity
multiple sclerosis