Pharmacological inhibition of EZH2 disrupts the female germline epigenome.

Lexie ProkopukKirsten HoggPatrick S Western

Published in: Clinical epigenetics (2018)

Together, these data demonstrate that drugs targeting EZH2 significantly affect the germline epigenome and, based on genetic models with oocyte-specific loss of EZH2 function, are likely to affect outcomes in offspring.

Keyphrases

dna methylation
long noncoding rna
long non coding rna
dna repair
genome wide
high fat diet
electronic health record
cancer therapy
gene expression
big data
copy number
metabolic syndrome
dna damage
oxidative stress
drug delivery
skeletal muscle
deep learning