An Advanced Twin-Screw Granulation Technology: The use of Non-Volatile Solvents with High Solubilizing Capacity.

Siva Satyanarayana KolipakaLaura Andrade JunqueiraSteven RossVivek GargMd Sadeque Hossein MithuSaumil BhattDennis Douroumis

Published in: AAPS PharmSciTech (2024)

Overall, the study demonstrated an innovative approach for the development of extruded granules by processing water-insoluble APIs with non-volatile solvents for enhanced dissolution rates at high drug loadings.

Keyphrases

ionic liquid
mass spectrometry
drug induced