Injectable, Antioxidative, and Tissue-Adhesive Nanocomposite Hydrogel as a Potential Treatment for Inner Retina Injuries.
Yi-Chen LiuYi-Ke LinYu-Ting LinChe-Wei LinGuan-Yu LanYu-Chia SuFung-Rong HuKai-Hsiang ChangVincent ChenYi-Cheun YehTa-Ching ChenJia-Shing YuPublished in: Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2024)
Reactive oxygen species (ROS) have been recognized as prevalent contributors to the development of inner retinal injuries including optic neuropathies such as glaucoma, non-arteritic anterior ischemic optic neuropathy, traumatic optic neuropathy, and Leber hereditary optic neuropathy, among others. This underscores the pivotal significance of oxidative stress in the damage inflicted upon retinal tissue. To combat ROS-related challenges, this study focuses on creating an injectable and tissue-adhesive hydrogel with tailored antioxidant properties for retinal applications. GelCA, a gelatin-modified hydrogel with photo-crosslinkable and injectable properties, is developed. To enhance its antioxidant capabilities, curcumin-loaded polydopamine nanoparticles (Cur@PDA NPs) are incorporated into the GelCA matrix, resulting in a multifunctional nanocomposite hydrogel referred to as Cur@PDA@GelCA. This hydrogel exhibits excellent biocompatibility in both in vitro and in vivo assessments, along with enhanced tissue adhesion facilitated by NPs in an in vivo model. Importantly, Cur@PDA@GelCA demonstrates the potential to mitigate oxidative stress when administered via intravitreal injection in retinal injury models such as the optic nerve crush model. These findings underscore its promise in advancing retinal tissue engineering and providing an innovative strategy for acute neuroprotection in the context of inner retinal injuries.
Keyphrases
- optic nerve
- tissue engineering
- optical coherence tomography
- oxidative stress
- hyaluronic acid
- diabetic retinopathy
- drug delivery
- reactive oxygen species
- dna damage
- cell death
- ischemia reperfusion injury
- anti inflammatory
- cancer therapy
- signaling pathway
- vascular endothelial growth factor
- diabetic rats
- machine learning
- climate change
- staphylococcus aureus
- mass spectrometry
- big data
- extracorporeal membrane oxygenation
- liver failure
- cerebral ischemia
- intensive care unit
- acute respiratory distress syndrome
- brain injury
- highly efficient
- high resolution
- mechanical ventilation