How abnormal is the normal? Clinical characteristics of CF patients with normal FEV1.
Malena Cohen-CymberknohElad Ben MeirSilvia GartnerJoel ReiterAngeles SpangenbergLaura GarrigaIris EisenstadtTomer IsraeliReuven TsabariDavid ShoseyovAlex Gileles-HillelOded BreuerNatalia SimanovskyEitan KeremPublished in: Pediatric pulmonology (2021)
Most CF patients with normal FEV1 have already physiological and structural lung abnormalities which were associated with more PEx and IV antibiotic treatment. Further studies are needed to determine if better adherence to the currently used therapies and the new cystic fibrosis transmembrane modulators will prevent the progression of lung disease.