Moloney leukemia virus 10 (MOV10) inhibits the degradation of APOBEC3G through interference with the Vif-mediated ubiquitin-proteasome pathway.

Cancan ChenXiaocao MaQifei HuXinghua LiFeng HuangJunsong ZhangTing PanJinyu XiaChao LiuHui Zhang

Published in: Retrovirology (2017)

Our results demonstrate a novel mechanism involved in the anti-HIV-1 function of MOV10. Given that both MOV10 and A3G belong to the interferon antiviral system, their synergistic inhibition of HIV-1 suggests that these proteins may play complicated roles in antiviral functions.

Keyphrases

antiretroviral therapy
hiv positive
hiv testing
hiv infected
human immunodeficiency virus
hepatitis c virus
hiv aids
men who have sex with men
acute myeloid leukemia
dendritic cells
bone marrow
small molecule
cancer therapy
drug delivery