Lung Transcriptomics Links Emphysema to Barrier Dysfunction and Macrophage Subpopulations.
Robin LuAndrew GregoryRahul SuryadevaraZhonghui XuDhawal JainJarrett D MorrowBrian D HobbsJeong Hyun YunNoah LichtblauRobert ChaseJeffrey L CurtisMaor SaulerBrian J BartholmaiEdwin K SilvermanCraig P HershPeter J CastaldiAdel Boueiznull nullPublished in: American journal of respiratory and critical care medicine (2024)
This study identified emphysema-related changes in gene expression and alternative splicing, cell-type specific dysregulated pathways, and instances of shared pathway dysregulation between blood and lung.