IDH Mutant Myeloid Neoplasms are Associated with Seronegative Rheumatoid Arthritis and Innate Immune Activation.
Lih En HongMihir D WechalekarMonika M KutynaAnnabelle G SmallKelly LimChloe A L Thompson-PeachJoule J LiRakchha ChhetriHamish S ScottAnna L BrownChristopher N HahnDavid T YeungSalvia SajidNirmal RobinsonRanjeny ThomasSusan BranfordRichard J J D'AndreaSaumya E E SamaraweeraMirinal S PatnaikSusanna M ProudmanDaniel ThomasChung Hoow KokMithun Vinod ShahDevendra K HiwasePublished in: Blood (2024)
High prevalence of IDH-mutations in seronegative rheumatoid arthritis (RA) with myeloid neoplasm, elevated 2-hydroxyglutarate, dysregulated innate immunity and pro-inflammatory microenvironment, suggests causative association between IDH-mutations and seronegative RA. Our findings merit investigation of IDH-inhibitors as therapeutics for seronegative IDH-mutated RA.