Medulloblastoma epigenetics and the path to clinical innovation.
Amanda R HaltomStephanie A TollDonghang ChengShinji MaegawaVidya GopalakrishnanSoumen KhatuaPublished in: Journal of neuro-oncology (2020)
The widespread epigenetic alterations present in these tumors has generated intense interest in their use as therapeutic targets. We provide an assessment of the progress that has been made towards the development of molecular subtypes-targeted therapies and the current status of clinical trials that have leveraged these recent advances.