Sub-additive (antagonistic) interaction of lacosamide with lamotrigine and valproate in the maximal electroshock-induced seizure model in mice: an isobolographic analysis.
Jarogniew J LuszczkiMaria Kondrat-WróbelMirosław ZagajaSławomir KarwanHubert BojarZbigniew PlewaMagdalena Florek-ŁuszczkiPublished in: Pharmacological reports : PR (2020)
The antagonistic pharmacodynamic interaction among LCM, LTG and VPA in the MES test in mice cannot be transferred to clinical settings and this unfavorable combination should not be recommended for patients with epilepsy.