RGS6 negatively regulates inhibitory G protein signaling in VTA dopamine neurons and positively regulates binge-like alcohol consumption in mice.

Margot C DeBakerEric H MittenTimothy R RoseEzequiel Marron Fernandez de VelascoRunbo GaoAnna M LeeKevin Wickman

Published in: British journal of pharmacology (2023)

R-dependent inhibitory G protein signaling pathways in mouse VTA DA neurons and exerts a sex-dependent positive influence on binge-like alcohol consumption in adult mice. As such, RGS6 may represent a new diagnostic and/or therapeutic target for alcohol use disorder.

Keyphrases

alcohol consumption
alcohol use disorder
high fat diet induced
spinal cord
signaling pathway
type diabetes
wild type
metabolic syndrome
epithelial mesenchymal transition
adipose tissue
oxidative stress
skeletal muscle
induced apoptosis
childhood cancer
anorexia nervosa