Intracerebroventricular administration of the exercise hormone irisin or acute strenuous exercise alleviates epileptic seizure-induced neuroinflammation and improves memory dysfunction in rats.

Zarife Nigâr Ozdemir-KumralTuğçe AkgünCeren HaşimEzgi UlusoyMehmet Kaan KalpakçıoğluMuhammet Ferzan YükselTunahan OkumuşZeynep UsDilek AkakınMeral YükselZafer GörenTessa Corrine Catherina Jaspers

Published in: BMC neuroscience (2024)

In conclusion, acute high-intensity exercise or exogenously administered irisin provides neuroprotection by maintaining the balance of excitatory/inhibitory neurotransmitters and oxidant/antioxidant systems.

Keyphrases

high intensity
resistance training
liver failure
drug induced
respiratory failure
oxidative stress
aortic dissection
traumatic brain injury
physical activity
cerebral ischemia
anti inflammatory
high glucose
diabetic rats
lipopolysaccharide induced
working memory
mouse model
endothelial cells