Pretreated MSCs with IronQ Transplantation Attenuate Microglia Neuroinflammation via the cGAS-STING Signaling Pathway.
Guoqiang YangJiraporn KantapanMaryam MazharQiongdan HuXue BaiYuanxia ZouHonglian WangSijin YangWang LiNathupakorn DechsupaPublished in: Journal of inflammation research (2024)
These findings suggest that pretreated MSCs with IronQ demonstrate a synergistic effect in alleviating neuroinflammation, thereby improving neurological function, which is achieved through the inhibition of the cGAS-STING signaling pathway.
Keyphrases
- signaling pathway
- mesenchymal stem cells
- pi k akt
- lipopolysaccharide induced
- cerebral ischemia
- lps induced
- traumatic brain injury
- inflammatory response
- epithelial mesenchymal transition
- umbilical cord
- cognitive impairment
- induced apoptosis
- cell therapy
- neuropathic pain
- bone marrow
- oxidative stress
- blood brain barrier