Direct Synthesis of 3-Aryl Substituted Isocoumarins and Phthalides through Palladium Acetate Catalyzed C(sp 2 )-H Activation in Ionic Liquids.
Andrea AloiaMichele CasielloLucia D'AccoltiCaterina FuscoAngelo NacciAntonio MonopoliPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2022)
A novel Pd-catalysed oxidative coupling between benzoic acids and vinylarenes or acrylates to furnish isocoumarins and phthalides is reported. The reaction proceeds smoothly in molten tetrabutylammonium acetate via a selective C-H bond activation, with very low percentage of ligand-free palladium acetate as the catalyst, under atmospheric pressure of oxygen. Sub-stoichiometric amount of copper acetate is also required as a reoxidant for the palladium.