Lignin/Puerarin Nanoparticle-Incorporated Hydrogel Improves Angiogenesis through Puerarin-Induced Autophagy Activation.

Yingjing PanTianci Lin Long-Quan ShaoYulin ZhangQiao HanLiyuan ShengRui GuoTing SunYanli Zhang

Published in: International journal of nanomedicine (2023)

The puerarin-attached lignin nanoparticle-incorporated hydrogel effectively alleviated blood perfusion in mice with hind-limb ischemia. Puerarin has a prominent proangiogenic effect. The potential mechanisms might be that puerarin-mediated autophagy activation and increase in PPARβ/δ.

Keyphrases

cell death
drug delivery
oxidative stress
wound healing
signaling pathway
ionic liquid
endothelial cells
high glucose
diabetic rats
insulin resistance
magnetic resonance imaging
vascular endothelial growth factor
high fat diet induced