New prospects of mesenchymal stem cells for ameliorating temporal lobe epilepsy.
Neveen A SalemMarwa El-ShamarkaYasser KhadrawyShaimaa El-ShebineyPublished in: Inflammopharmacology (2018)
Temporal lobe epilepsy (TLE) is present in 30% of epileptic patients and does not respond to conventional treatments. Bone marrow derived mesenchymal stem cells (BMSCs) induce endogenous neural stem cells, inhibit neurodegeneration, and promote brain self-repair mechanisms. The present study addresses the feasibility of BMSCs transplantation against pilocarpine-induced TLE experimentally. BMSCs were injected either intravenously (IV) or in hippocampus bilaterally (IC). Increased cell count of BMSCs was achieved via IC route. BMSCs treatment ameliorated the pilocarpine-induced neurochemical and histological changes, retained amino acid neurotransmitters to the normal level, downregulated the immunoreactivity to insulin growth factor-1 receptor, synaptophysin, and caspase-3 and reduced oxidative insult and inflammatory markers detected in epileptic model. It is worth noting that BMSCs IC-administered showed more pronounced effects than those administered via IV route. BMSCs transplantation presents a promise for TLE treatment that has to be elucidated clinically.
Keyphrases
- temporal lobe epilepsy
- growth factor
- mesenchymal stem cells
- bone marrow
- cell therapy
- high glucose
- end stage renal disease
- type diabetes
- newly diagnosed
- amino acid
- diabetic rats
- chronic kidney disease
- ejection fraction
- cell death
- endothelial cells
- single cell
- umbilical cord
- multiple sclerosis
- peritoneal dialysis
- drug induced
- big data
- patient reported outcomes
- binding protein
- stress induced