Clodronic Acid has Strong Inhibitory Interactions with the Urease Enzyme of Helicobacter Pylori: Computer-aided Design and in vitro Confirmation.
Mohsen Karami FathSaeed KhaliliMasoud Mashhadi Akbar BoojarZahra Sadat HashemiMahboubeh ZareiPublished in: Current computer-aided drug design (2023)
Clodronic acid has better HP urease inhibition potential than AHA. Given its approved status, the development of a repurposed drug based on Clodronic acid would require less time and cost. Further, in vivo studies would unveil the efficacy of Clodronic acid as a urease inhibitor.