Genomic Epidemiologic Investigation of a Multispecies Hospital Outbreak of NDM-5-Producing Enterobacterales Infections.

Nathan J RaabeAbby L ValekMarissa P GriffithEmma MillsKady WaggleVatsala Rangachar SrinivasaAshley M AyresClaire BradfordHannah CreagerLora L PlessAlexander J SundermannDaria Van TyneGraham M SnyderLee H Harrison

Published in: medRxiv : the preprint server for health sciences (2023)

5.We investigated a multispecies outbreak of Enterobacterales harboring the same New-Delhi metallo-β-lactamase-encoding plasmid using both traditional infection prevention and genomic approaches. Our investigation revealed a complex outbreak involving 7 bacterial species, including both bacterial transmission and plasmid transfer events.

Keyphrases

escherichia coli
klebsiella pneumoniae
crispr cas
copy number
gram negative
healthcare
multidrug resistant
mass spectrometry
gene expression
acute care
atomic force microscopy
single molecule
drug induced
electron transfer