Polygenic Risk Score Associates with Atherosclerotic Plaque Characteristics at Autopsy.
Anne CornelissenNeel V GadhokeKathleen A RyanChani J HodonskyRebecca MitchellNathan A BihlmeyerThuyVy DuongZhifen ChenArmelle DikongueAtsushi SakamotoYu SatoRika KawakamiMasayuki MoriKenji KawaiRaquel FernandezSaikat Kumar B GhoshRyan BraumannBiniyam AbebeRobert KutysMatthew KutynaMaria E RomeroFrank D KolodgieClint T MillerCharles C HongMegan L GroveJennifer A BrodyNona SotoodehniaDan E ArkingHeribert SchunkertBraxton D MitchellLiang GuoRenu VirmaniAloke V FinnPublished in: bioRxiv : the preprint server for biology (2023)
A polygenic risk score, generated from 291 known CAD risk loci, was assessed in 954 subjects within the CVPath Sudden Death Registry. Histopathologic examination of the coronary arteries was performed in all subjects. Subjects in the highest PRS quintile exhibited more severe atherosclerosis as compared to subjects in the lowest quintile, with a greater plaque burden, more calcification, and a higher frequency of plaque rupture.