MiRNAs in renal cell carcinoma.

Jesús Miranda-PomaLucía Trilla-FuertesElena López-CamachoAndrea Zapater-MorosRocío López-VacasMaría Isabel Lumbreras-HerreraAna Pertejo-FernandezJuan Ángel Fresno-VaraEnrique Espinosa-ArranzAngelo Gámez-PozoÁlvaro Pinto-Marín

Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2022)

MicroRNAs (miRNAs) are small RNA sequences that act as post-transcriptional regulatory genes to control many cellular processes through pairing bases with a complementary messenger RNA (mRNA). A single miRNA molecule can regulate more than 200 different transcripts and the same mRNA can be regulated by multiple miRNAs. In this review, we highlight the importance of miRNAs and collect the existing evidence on their relationship with kidney cancer.

Keyphrases

renal cell carcinoma
transcription factor
gene expression
papillary thyroid
squamous cell
oxidative stress
heat shock
lymph node metastasis