Mechanisms of reduced leptin-mediated satiety signaling during obesity.

Sung Jin ParkYang YuCarter G ZidesMichael J Beyak

Published in: International journal of obesity (2005) (2022)

This study suggests that obesity impairs vagal afferent sensitivity via SOCS3 and PTP1B, likely as a consequence of obesity-induced hyperleptinemia. The mechanisms underlying leptin resistance appear also to cause a more global impairment of satiety-related vagal afferent responsiveness.

Keyphrases

insulin resistance
metabolic syndrome
weight loss
high fat diet induced
type diabetes
weight gain
skeletal muscle
drug induced
oxidative stress