[18F]-C-SNAT4: an improved caspase-3-sensitive nanoaggregation PET tracer for imaging of tumor responses to chemo- and immunotherapies.
Min ChenZixin ChenJessa B CastilloLiyang CuiKaixiang ZhouBin ShenJinghang XieFrederick T ChinJianghong RaoPublished in: European journal of nuclear medicine and molecular imaging (2021)
The uptake of [18F]-C-SNAT4 in tumors received chemotherapy and immunotherapy is positively correlated with the tumor apoptotic level and the treatment efficacy. [18F]-C-SNAT4 PET imaging can monitor tumor response to two different treatment modalities and predict the therapeutic efficacy in preclinical mouse models.