Daily monitoring of viral load measured as SARS-CoV-2 antigen and RNA in blood, IL-6, CRP and complement C3d predicts outcome in patients hospitalized with COVID-19.
Claus Lohman BrasenHenry ChristensenDorte A OlsenSøren KahnsRikke F AndersenJeppe B MadsenAmanda LassenHelene KierkegaardAnders JensenThomas V SydenhamJonna S MadsenJens K MøllerIvan BrandslundPublished in: Clinical chemistry and laboratory medicine (2021)
Viral antigen is cleared in parallel with the virus RNA levels. The levels of antigens and SARS-CoV-2 RNA in the blood correlates with the level of IL-6, inflammation, respiratory failure and death. We propose that the antigens levels together with RNA in blood can be used to predict the severity of disease, outcome, and the clearance of the virus from the body.
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- respiratory failure
- end stage renal disease
- nucleic acid
- newly diagnosed
- ejection fraction
- oxidative stress
- chronic kidney disease
- extracorporeal membrane oxygenation
- dendritic cells
- mechanical ventilation
- physical activity
- prognostic factors
- peritoneal dialysis
- intensive care unit
- patient reported outcomes
- acute respiratory distress syndrome