Galectin-3 and RAGE differentially control advanced glycation endproduct-induced collagen damage in murine intervertebral disc organ culture.

Zachary S Gallate Danielle N D'ErminioPhilip NasserDamien M LaudierJames C Iatridis

Published in: JOR spine (2023)

These findings suggest both RAGE and Gal3 are important in the IVD response to AGEs and highlight Gal3 as an important receptor with protective effects on collagen damage. This research improves understanding the mechanisms of AGE-induced IVD degeneration and suggests Gal3 receptor modulation as a potential target for preventative and therapeutic treatment for IVD degeneration.

Keyphrases

high glucose
diabetic rats
oxidative stress
drug induced
binding protein
combination therapy