A multidimensional analysis reveals distinct immune phenotypes and tertiary lymphoid structure-like aggregates in the bone marrow of pediatric acute myeloid leukemia.
Joost B KoedijkInge van der WerfLivius PenterMarijn A VermeulenFarnaz BarnehAlicia PerzolliJoyce I Meesters-EnsingMarta FioccoHester A de Groot-KrusemanRubina MoeniralamKristina Bang ChristensenBillie PorterKathleen PfaffJacqueline S GarciaScott J RodigCatherine J WuHenrik HasleStefan NierkensMirjam E BelderbosC Michel ZwaanOlaf HeidenreichPublished in: medRxiv : the preprint server for health sciences (2023)
The limited response rates to T cell-directed immunotherapies remain a major challenge in AML. This study reveals the spatial organization of the tumor immune microenvironment in pediatric AML, identifies that immune aggregates associate with response to T cell-directed immunotherapy in the adult setting, and provides starting points for future investigations into immunomodulatory mechanisms in AML.