Chemotherapy outcomes in EGFR-TKI resistant patients with common and uncommon EGFR mutation: An exploratory retrospective cohort study.
Chien-Yu LinChia-Hao HuChia-Fu HsuJeng-Shiuan TsaiChian-Wei ChenChia-Yin LinChao-Chun ChangYi-Ting YenYau-Lin TsengPo-Lan SuChien-Chung LinPublished in: Thoracic cancer (2023)
This study suggests that patients with uncommon EGFR mutations have poorer chemotherapy responses and shorter survival than those with common EGFR mutations. The development of new treatment strategies for these patients remains an unmet need.
Keyphrases
- tyrosine kinase
- small cell lung cancer
- epidermal growth factor receptor
- end stage renal disease
- advanced non small cell lung cancer
- ejection fraction
- chronic kidney disease
- locally advanced
- prognostic factors
- type diabetes
- metabolic syndrome
- squamous cell carcinoma
- radiation therapy
- insulin resistance
- free survival
- chronic myeloid leukemia