Characterization and Validation of Canine P-Glycoprotein-Deficient MDCK II Cell Lines for Efflux Substrate Screening.

Dong YeAnna HarderZhizhou FangManuel WeinheimerLoic LaplancheMario Mezler

Published in: Pharmaceutical research (2020)

cP-gp deficient MDCKII ZFN models are reliable tools to identify MDR1 and BCRP substrates and useful for predicting efflux liability for brain penetration.

Keyphrases

multidrug resistant
resting state
white matter
wild type
functional connectivity
cerebral ischemia
multiple sclerosis
brain injury
amino acid
structural basis
subarachnoid hemorrhage