Changes in RANKL and TRAcP 5b after discontinuation of denosumab suggest RANKL mediated formation of osteoclasts results in the increased bone resorption.

Anne Sophie Koldkjær Sølling Torben Harsløf Niklas Rye Jørgensen Bente Lomholt Langdahl

Published in: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2022)

Following discontinuation of long-term DMAB, we find high levels of RANKL, which most likely result in an increase in the number of active osteoclasts (illustrated by TRAcP5b) causing an increased bone turnover.

Keyphrases

bone loss
bone mineral density
postmenopausal women
body composition
giant cell
soft tissue