Ketogenesis Attenuates KLF5-Dependent Production of CXCL12 to Overcome the Immunosuppressive Tumor Microenvironment in Colorectal Cancer.

Ruozheng WeiYuning ZhouChang LiPiotr RychahouShulin ZhangWilliam B TitlowGreg BaumanYuanyuan WuJinpeng LiuChi WangHeidi L WeissB Mark Evers Qingding Wang

Published in: Cancer research (2022)

This study identifies ketogenesis as a critical regulator of the tumor microenvironment in colorectal cancer and suggests the potential for ketogenic diets as a metabolic strategy to overcome immunosuppression and prolong survival. See related commentary by Montrose and Galluzzi, p. 1464.

Keyphrases

transcription factor
genome wide
gene expression
risk assessment
human health
drug induced