Nigral overexpression of α-synuclein in a rat Parkinson's disease model indicates alterations in the enteric nervous system and the gut microbiome.

Sarah M O'Donovan Erin K Crowley Jillian R-M Brown Orla O'SullivanOlivia F O'LearySuzanne TimmonsYvonne M Nolan David J Clarke Niall P Hyland Susan A Joyce Aideen M Sullivan Cora O'Neill

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2019)

These results show that developing nigral α-synuclein pathology in this PD model exerts significant alterations on the enteric nervous system (ENS) and gut microbiome that are receptive to modification by exercise. This highlights brain to gut communication as an important mechanism in PD pathology.

Keyphrases

cell proliferation
white matter
resting state
transcription factor
functional connectivity
brain injury