Involvement of the epidermal growth factor receptor in IL-13-mediated corticosteroid-resistant airway inflammation.
Elizabeth R DaviesJeanne Marie PerotinJoanne F C KellyRatko DjukanovićDonna E DaviesHans Michael Haitchinull nullPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2020)
Detailed dissection of those molecular pathways that are downstream of IL-13 and utilize the ERBB receptor and ligand family to drive corticosteroid-refractory inflammation should enhance the development of new treatments that target this sub-phenotype(s) of severe asthma, where there is an unmet need.