Preclinical study in a postoperative pain model to investigate the action of ketamine, lidocaine, and ascorbic acid in reversing fentanyl-induced, non-glutamate-dependent hyperalgesia.
Marina Ayres DelgadoLuana Assis FerreiraBianka Jaciara Dos Santos GomesIsis Katarine Orlandi LeiteMarcus Vinícius GomezCélio Castro-JuniorPublished in: Pain reports (2023)
Fentanyl induced a hyperalgesic effect that last few days in a postoperative model of pain. Hyperalgesic effect was not totally inhibited by ketamine and lidocaine in rats. Increased glutamate release was not the main molecular mechanism of fentanyl-induced hyperalgesia.