Altered gene expression in CHO cells following polyamine starvation.

Berta Capella RocaPadraig DoolanNiall BarronFiona O'NeillMartin Clynes

Published in: Biotechnology letters (2020)

Growth-arrest induced by polyamine deprivation was associated with significant alterations in levels of mRNAs associated with cell cycle progression, DNA repair, RNA splicing, ER trafficking and membrane signalling as well as p53 and apoptosis-related pathways.

Keyphrases

cell cycle
dna repair
cell cycle arrest
gene expression
induced apoptosis
cell proliferation
dna damage
cell death
endoplasmic reticulum stress
pi k akt
oxidative stress
dna damage response
dna methylation
signaling pathway
breast cancer cells
genome wide analysis