Synthesis and antioxidant activities of benzylic bromophenols inclusive of natural products.

The synthesis of natural products 2-(2,3-dibromo-4,5-dihydroxyphenyl)acetic acid ( 1 ) and 2-(2,6-dibromo-3,5-dihydroxyphenyl)acetic acid ( 2 ) and as well as their derivatives 25 and 26 were carried out by substitution, hydrolysis and demethylation reactions of the corresponding four benzyl bromides. The antioxidant potentials of benzylic acid-derived bromophenols were, for the first time, appraised by several outstanding bioanalytical methods. Besides these, we estimated the antioxidant effects which were studied using the methods of DPPH·, ABTS •+ scavenging activities, ferric (Fe 3+ ) and cupric (Cu 2+ ) ions and Fe 3+ -TPTZ reducing capacities. Benzylic acid-derived bromophenols were found as effective DPPH • , and ABTS •+ scavengers. The potential antioxidant activities of bromophenol derivatives 1, 2 and 17-28 were compared to standard antioxidants including BHA, BHT, α-Tocopherol, and Trolox, which is a water-soluble analog of vitamin E. We expect that this innovative work will direct future studies exploring the antioxidant properties of food, medicinal, and industrial applications.